Properties
Enalapril maleate, the active ingredient of Korandil® inhibits the angiotensin converting enzyme (ACE), which leads to the suppression of the renin-angiotensis-aldosterone system.
Oral enalapril it is rapidly absorbed, with peak serum concentrations of enalapril occurring within one hour. Following absorption, it is rapidly and extensively hydrolysed to enalaprilat, occur about 4 hours after an oral dose of enalapril. Enalaprilat binding to human plasma proteins does not exceed 60%.
Indication
Korandil® is indicated for the treatment of hypertension, symptomatic heart failure and prevention of symptomatic heart failure in patients with asymptomatic left ventricular dysfunction (ejection fraction <35%).
Dosage
Adults: In hypertension the recommended starting dose is 5 to 20mg, depending on the degree of hypertension. The usual maintenance dose is 20mg daily and maximum dose is 40mg daily.
Children: there is a limited clinical experience of the use of Korandil® in hypertensive paediatric patients.
Side Effect
Undersirable effects reported for enalapril include: headache, blurred vision, dizziness, hypotension, cough, nausea, hypersensivity reactions, anaemia, asthenia, fatigue, gastrointestinal disturbances, hyperkalaemia, increase in serum creating, etc.