Presentation
Film-Coated Tablets 250 and 500mg.
Properties
Ciprofloxacin, the active ingredient of Zindolin® is a fluorinated 4-quinolone antimicrobial agent. Ciprofloxacin’s primary mechanism of action, like all fluoroquinolones, is inhibition of DNA gyrase (topoisomerase). It is rapidly and well absorbed from the gastrointestinal tract following oral administration in the fasting state and is eliminated from the body predominantly by the kidneys by a combination of glomerular filtration and tubular secretion.
Indications
Zindolin® is indicated for the treatment of the following infections caused by sensitive bacteria:
1. Severe systematic infections.
2. Respiratory tract infections.
3. Ear, nose and throat infections.
4. Urinary tract infections.
5. Skin and soft tissue infections.
6. Gastrointestinal infections.
7. Eye infections.
8. Biliary tract infections.
9. Intra-abdominal and pelvic infections.
10. Bone and joint infections.
11. Gonorrhoea
Dosage
Adult:
The dosage range from 250mg to 750mg twice daily depending on the severity and nature of infection. In patients with severe renal impairment the dosage should be reduced by half. The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings. For acute infections the usual treatment period is 5-10 days. Generally, treatment should be continued for at least 3 days after the signs and symptoms of infection have disappeared.
Adolescents and children:
The use of Zindolin® is not recommended.
Side-effects
Ciprofloxacin is generally well tolerated. The most frequently reported adverse reactions are nausea, diarrhoea and rash. Also, there have been observed: hypersensitivity reactions, gastrointestinal and CNS disturbances, changes in haematological functions. For more information please see the summary of product characteristics.